Castejón-Vega, Beatriz and Battino, Maurizio and Quiles, José L. and Bullon, Beatriz and Cordero, Mario D. and Bullón, Pedro UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED (2021) Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre. Antioxidants, 10 (1). p. 95. ISSN 2076-3921
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Abstract
The Papillon–Lefèvre syndrome (PLS) is a rare autosomal recessive disorder caused by mutations in the Cathepsin C (CTSC) gene, characterized by periodontitis and palmoplantar hyperkeratosis. The main inflammatory deficiencies include oxidative stress and autophagic dysfunction. Mitochondria are the main source of reactive oxygen species; their impaired function is related to skin diseases and periodontitis. The mitochondrial function has been evaluated in PLS and mitochondria have been targeted as a possible treatment for PLS. We show for the first time an important mitochondrial dysfunction associated with increased oxidative damage of mtDNA, reduced CoQ10 and mitochondrial mass and aberrant morphologies of the mitochondria in PLS patients. Mitochondrial dysfunction, determined by oxygen consumption rate (OCR) in PLS fibroblasts, was treated with CoQ10 supplementation, which determined an improvement in OCR and a remission of skin damage in a patient receiving a topical administration of a cream enriched with CoQ10 0.1%. We provide the first evidence of the role of mitochondrial dysfunction and CoQ10 deficiency in the pathophysiology of PLS and a future therapeutic option for PLS.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Papillon–Lefèvre syndrome, Mitochondria, Coenzyme Q10. |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 11:09 |
| Last Modified: | 07 Jul 2023 10:16 |
| URI: | http://repositorio.funiber.org/id/eprint/104 |
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- Castejón-Vega, Beatriz and Battino, Maurizio and Quiles, José L. and Bullon, Beatriz and Cordero, Mario D. and Bullón, Pedro Potential Role of the Mitochondria for the Dermatological Treatment of Papillon-Lefèvre. (deposited 20 May 2021 11:09) [Currently Displayed]
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