Rivas-García, Lorenzo and Quiles, José L. and Roma-Rodrigues, Catarina and Raposo, Luis R. and Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Esteban-Muñoz, Adelaida and Varela-López, Alfonso and García, Laura Carrera and Cianciosi, Danila and Forbes Hernandez, Tamara Y. and Battino, Maurizio and Llopis, Juan and Fernandes, Alexandra R. and Baptista, Pedro V. and Sánchez-González, Cristina UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease. Food and Chemical Toxicology, 149. p. 112018. ISSN 0278-6915
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Abstract
Edible flowers are being used as a new ingredient in modern gastronomy. Recently, these products have also gained interest as an important source of phenolic compounds with potential for biomedical applications. The present work studied a methanolic extract of Rosa x hybrida in which 35 individual phenolic compounds were identified. The extract has been evaluated for its antiproliferative properties in ovarian carcinoma cells. Results showed that the antiproliferative effect was associated with the induction of autophagy and apoptosis with the concomitant ROS increase probably related to mitochondria dysfunction. These antiproliferative effects might be associated with some components of the extract such as quercetin. The extract did not induce damage in healthy cells and that it was able to improve the wound healing activity. The present study also evaluated the properties of the mentioned extract in vivo in C. elegans. Tests demonstrated a lack of toxicity in the worm model. Promising results have been obtained in transgenic strains of C. elegans that produce human beta amyloid peptide, suggesting the possible utility of the extract from the point of view of Alzheimer disease. Altogether, results suggest that Rosa x hybrida extracts could be a new tool for the development of functional foods.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Antioxidants; Autophagy; Edible flowers; Flavonoids; Polyphenols; ROS. |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 11:09 |
| Last Modified: | 03 Mar 2022 15:23 |
| URI: | http://repositorio.funiber.org/id/eprint/108 |
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- Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease. (deposited 20 May 2021 11:09) [Currently Displayed]
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- Rivas-García, Lorenzo and Quiles, José L. and Roma-Rodrigues, Catarina and Raposo, Luis R. and Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Esteban-Muñoz, Adelaida and Varela-López, Alfonso and García, Laura Carrera and Cianciosi, Danila and Forbes Hernandez, Tamara Y. and Battino, Maurizio and Llopis, Juan and Fernandes, Alexandra R. and Baptista, Pedro V. and Sánchez-González, Cristina Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease. (deposited 20 May 2021 11:09) [Currently Displayed]
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