Anderson, Rozalyn and Cordero, Mario D. and Bullón, Pedro and Ruiz-Cabello, Jesús and Robertson, Avril A B and Ryffel, Bernhard and Pérez-Pulido, Antonio J and Muntané, Jordi and Pérez-Alegre, Mónica and Andújar-Pulido, Eloísa and de la Cruz, Patricia and Cooper, Matthew A and Lendines-Cordero, Debora and Alcocer-Gómez, Elísabet and Castejón-Vega, Beatriz and Marín-Aguilar, Fabiola UNSPECIFIED, mario.cordero@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2019) NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity. The Journals of Gerontology: Series A, 75 (8). pp. 1457-1464. ISSN 1079-5006
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Abstract
The NLRP3 inflammasome has emerged as an important regulator of metabolic disorders and age-related diseases in NLRP3-deficient mice. In this article, we determine whether, in old mice C57BL6J, the NLRP3 inflammasome inhibitor MCC950 is able to attenuate age-related metabolic syndrome to providing health benefits. We report that MCC950 attenuates metabolic and hepatic dysfunction in aged mice. In addition, MCC950 inhibited the Pi3K/AKT/mTOR pathway, enhanced autophagy, and activated peroxisome proliferator-activated receptor-α in vivo and in vitro. The data suggest that MCC950 mediates the protective effects by the mammalian target of rapamycin inhibition, thus activating autophagy and peroxisome proliferator-activated receptor-α. In conclusion, pharmacological inhibition of NLRP3 in aged mice has a significant impact on health. Thus, NLRP3 may be a therapeutic target of human age-related metabolic syndrome.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | NLRP3 inflammasome; Aging; Autophagy; MCC950; PPARα. |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Articles and books |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 11:03 |
| Last Modified: | 03 Mar 2022 15:26 |
| URI: | https://repositorio.funiber.org/id/eprint/122 |
Available Versions of this Item
- NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity. (deposited 20 May 2021 11:03) [Currently Displayed]
Commentary/Response Threads
- Anderson, Rozalyn and Cordero, Mario D. and Bullón, Pedro and Ruiz-Cabello, Jesús and Robertson, Avril A B and Ryffel, Bernhard and Pérez-Pulido, Antonio J and Muntané, Jordi and Pérez-Alegre, Mónica and Andújar-Pulido, Eloísa and de la Cruz, Patricia and Cooper, Matthew A and Lendines-Cordero, Debora and Alcocer-Gómez, Elísabet and Castejón-Vega, Beatriz and Marín-Aguilar, Fabiola NLRP3 Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity. (deposited 20 May 2021 11:03) [Currently Displayed]
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