Nicolás-Ávila, José A. and Lechuga-Vieco, Ana V. and Esteban-Martínez, Lorena and Sánchez-Díaz, María and Díaz-García, Elena and Santiago, Demetrio J. and Rubio-Ponce, Andrea and Li, Jackson LiangYao and Balachander, Akhila and Quintana, Juan A. and Martínez-de-Mena, Raquel and Castejón-Vega, Beatriz and Pun-García, Andrés and Través, Paqui G. and Bonzón-Kulichenko, Elena and García-Marqués, Fernando and Cussó, Lorena and A-González, Noelia and González-Guerra, Andrés and Roche-Molina, Marta and Martin-Salamanca, Sandra and Crainiciuc, Georgiana and Guzmán, Gabriela and Larrazabal, Jagoba and Herrero-Galán, Elías and Alegre-Cebollada, Jorge and Lemke, Greg and Rothlin, Carla V. and Jimenez-Borreguero, Luis Jesús and Reyes, Guillermo and Castrillo, Antonio and Desco, Manuel and Muñoz-Cánoves, Pura and Ibáñez, Borja and Torres, Miguel and Ng, Lai Guan and Priori, Silvia G. and Bueno, Héctor and Vázquez, Jesús and Cordero, Mario D. and Bernal, Juan A. and Enríquez, José A. and Hidalgo, Andrés UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, mario.cordero@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2020) A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. Cell, 183 (1). 94-109.e23. ISSN 0092-8674
This is the latest version of this item.
Abstract
Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of the beating heart. It is unclear whether these cells, which are long-lived and rarely renew, manage to preserve homeostasis on their own. While analyzing macrophages lodged within the healthy myocardium, we discovered that they actively took up material, including mitochondria, derived from cardiomyocytes. Cardiomyocytes ejected dysfunctional mitochondria and other cargo in dedicated membranous particles reminiscent of neural exophers, through a process driven by the cardiomyocyte’s autophagy machinery that was enhanced during cardiac stress. Depletion of cardiac macrophages or deficiency in the phagocytic receptor Mertk resulted in defective elimination of mitochondria from the myocardial tissue, activation of the inflammasome, impaired autophagy, accumulation of anomalous mitochondria in cardiomyocytes, metabolic alterations, and ventricular dysfunction. Thus, we identify an immune-parenchymal pair in the murine heart that enables transfer of unfit material to preserve metabolic stability and organ function.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Macrophage; Mitochondria; Autophagy; Proteostasis; Phagocytosis; Heart. |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 11:02 |
| Last Modified: | 15 Jun 2023 14:38 |
| URI: | http://repositorio.funiber.org/id/eprint/124 |
Available Versions of this Item
- A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. (deposited 20 May 2021 11:02) [Currently Displayed]
Commentary/Response Threads
- Nicolás-Ávila, José A. and Lechuga-Vieco, Ana V. and Esteban-Martínez, Lorena and Sánchez-Díaz, María and Díaz-García, Elena and Santiago, Demetrio J. and Rubio-Ponce, Andrea and Li, Jackson LiangYao and Balachander, Akhila and Quintana, Juan A. and Martínez-de-Mena, Raquel and Castejón-Vega, Beatriz and Pun-García, Andrés and Través, Paqui G. and Bonzón-Kulichenko, Elena and García-Marqués, Fernando and Cussó, Lorena and A-González, Noelia and González-Guerra, Andrés and Roche-Molina, Marta and Martin-Salamanca, Sandra and Crainiciuc, Georgiana and Guzmán, Gabriela and Larrazabal, Jagoba and Herrero-Galán, Elías and Alegre-Cebollada, Jorge and Lemke, Greg and Rothlin, Carla V. and Jimenez-Borreguero, Luis Jesús and Reyes, Guillermo and Castrillo, Antonio and Desco, Manuel and Muñoz-Cánoves, Pura and Ibáñez, Borja and Torres, Miguel and Ng, Lai Guan and Priori, Silvia G. and Bueno, Héctor and Vázquez, Jesús and Cordero, Mario D. and Bernal, Juan A. and Enríquez, José A. and Hidalgo, Andrés A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. (deposited 20 May 2021 11:02) [Currently Displayed]
Actions (login required)
 |
View Item |
