Pistollato, Francesca and Forbes-Hernandez, Tamara Y. and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Elexpuru Zabaleta, Maria and Cianciosi, Danila and Giampieri, Francesca and Battino, Maurizio francesca.pistollato@uneatlantico.es, UNSPECIFIED, ruben.calderon@uneatlantico.es, roberto.ruiz@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2020) Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: A focus on human studies. Pharmacological Research, 152. p. 104579. ISSN 1043-6618
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Abstract
In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted and repetitive behaviors. On the other hand, transplantation of hematopoietic and mesenchymal stem cells in ASD children has been shown promising to stimulate the recruitment, proliferation, and differentiation of tissue-residing native stem cells, reducing inflammation, and improving some ASD symptoms. Moreover, several comorbidities have also been associated with ASD, such as immune dysregulation, gastrointestinal issues and gut microbiota dysbiosis. Non-pharmacological approaches, such as dietary supplementations with certain vitamins, omega-3 polyunsaturated fatty acids, probiotics, some phytochemicals (e.g., luteolin and sulforaphane), or overall diet interventions (e.g., gluten free and casein free diets) have been considered for the reduction of such comorbidities and the management of ASD. Here, interventional studies describing pharmacological and non-pharmacological treatments in ASD children and adolescents, along with stem cell-based therapies, are reviewed.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Autism spectrum disorder; Pharmacological interventions; Non-Pharmacological strategies; Stem cell therapies; Dietary supplementations; Exclusion diets. |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 11:00 |
| Last Modified: | 03 Jul 2023 08:47 |
| URI: | http://repositorio.funiber.org/id/eprint/125 |
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- Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: A focus on human studies. (deposited 20 May 2021 11:00) [Currently Displayed]
Commentary/Response Threads
- Pistollato, Francesca and Forbes-Hernandez, Tamara Y. and Calderón Iglesias, Rubén and Ruiz Salces, Roberto and Elexpuru Zabaleta, Maria and Cianciosi, Danila and Giampieri, Francesca and Battino, Maurizio Pharmacological, non-pharmacological and stem cell therapies for the management of autism spectrum disorders: A focus on human studies. (deposited 20 May 2021 11:00) [Currently Displayed]
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