Giampieri, Francesca and Afrin, Sadia and Stewart, Derek and McDougall, Gordon and Brennan, Rex and Blyth, Lesley and Gasparrini, Massimiliano and Mazzoni, Luca and Capocasa, Franco and Alvarez-Suarez, José M. and Bompadre, Stefano and Nogueira Brás de Oliveira, Pedro and N. Santos, Claudia and Masias Vergara, Manuel and Agudo Toyos, Pablo and Crespo-Álvarez, Jorge and Mezzetti, Bruno and Forbes-Hernandez, Tamara Y. and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, manuel.masias@uneatlantico.es, pablo.agudo@uneatlantico.es, jorge.crespo@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion. Molecules, 23 (8). p. 1918. ISSN 1420-3049
This is the latest version of this item.
|
Text
molecules-23-01918.pdf - Published Version Available under License Creative Commons Attribution. Download (991kB) | Preview |
Abstract
Berry fruits are rich in nutrients and polyphenols, providing potential health benefits. Understanding the factors that affect their bioavailability is becoming of utmost importance for evaluating their biological significance and efficacy as functional food. In this study, the phytochemical composition and the total antioxidant capacity of different varieties of five berries (blackberry, blackcurrant, blueberry, raspberry, and strawberry) were evaluated after an in vitro gastrointestinal digestion process. The cultivar of each berry that showed the higher content of total phenols and flavonoids was selected to study its cytotoxic effect on human hepatoma cells. Digestion resulted in a high reduction (p ˂ 0.05) of total phenolic, flavonoid and anthocyanin contents and total antioxidant capacity, in the “IN” samples compared to the “OUT” extracts, which represent the “serum-available” and the “colon-available” fractions, respectively. Incubation of the digested fraction for 24 h didn’t exert any effect on cellular viability, while a dose- and time-dependent cytotoxicity was observed after 48 h and 72 h of incubation for all the berries analyzed. Our results suggest that the approach proposed in this work may represent a rapid tool for evaluating and identifying new berries with increased phytochemical bioavailability, highlighting their antiproliferative agents after an in vitro digestion.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Berry; Polyphenols; In vitro gastrointestinal digestion; Bioavailability; Cytotoxicity. |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:59 |
| Last Modified: | 08 Jul 2021 22:25 |
| URI: | http://repositorio.funiber.org/id/eprint/130 |
Available Versions of this Item
- Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion. (deposited 20 May 2021 10:59) [Currently Displayed]
Commentary/Response Threads
- Giampieri, Francesca and Afrin, Sadia and Stewart, Derek and McDougall, Gordon and Brennan, Rex and Blyth, Lesley and Gasparrini, Massimiliano and Mazzoni, Luca and Capocasa, Franco and Alvarez-Suarez, José M. and Bompadre, Stefano and Nogueira Brás de Oliveira, Pedro and N. Santos, Claudia and Masias Vergara, Manuel and Agudo Toyos, Pablo and Crespo-Álvarez, Jorge and Mezzetti, Bruno and Forbes-Hernandez, Tamara Y. and Battino, Maurizio Phytochemical Composition and Cytotoxic Effects on Liver Hepatocellular Carcinoma Cells of Different Berries Following a Simulated In Vitro Gastrointestinal Digestion. (deposited 20 May 2021 10:59) [Currently Displayed]
Actions (login required)
 |
View Item |
