Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage

Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Reboredo-Rodriguez, Patricia and Cianciosi, Danila and Mezzetti, Bruno and Quiles, José L. and Bompadre, Stefano and Battino, Maurizio and Giampieri, Francesca UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2017) Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage. Nutrients, 9 (6). p. 605. ISSN 2072-6643

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Abstract

Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 μg/mL)-based formulations supplemented with Coenzyme Q10 (100 μg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents.

Item Type:	Article
Commentary on:	Eprints 0 not found.
Uncontrolled Keywords:	Skin damage, UVA-radiation, ROS, Apoptosis, Mitochondria functionality, Antioxidant defense, Inflammatory status, Strawberry polyphenols; Cosmetic formulation.
Subjects:	Subjects > Biomedicine
Divisions:	Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production
SWORD Depositor:	Users 0 not found.
Depositing User:	Sr Bibliotecario
Date Deposited:	20 May 2021 10:56
Last Modified:	24 Sep 2021 07:24
URI:	http://repositorio.funiber.org/id/eprint/141

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• Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage. (deposited 20 May 2021 10:56) [Currently Displayed]

Commentary/Response Threads

• Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Reboredo-Rodriguez, Patricia and Cianciosi, Danila and Mezzetti, Bruno and Quiles, José L. and Bompadre, Stefano and Battino, Maurizio and Giampieri, Francesca Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage. (deposited 20 May 2021 10:56) [Currently Displayed]

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