Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial

Hiensch, Anouk E. and Depenbusch, Johanna and Schmidt, Martina E. and Monninkhof, Evelyn M. and Peláez, Mireia and Clauss, Dorothea and Gunasekara, Nadira and Zimmer, Philipp and Belloso, Jon and Trevaskis, Mark and Rundqvist, Helene and Wiskemann, Joachim and Müller, Jana and Sweegers, Maike G. and Fremd, Carlo and Altena, Renske and Gorecki, Maciej and Bijlsma, Rhodé and van Leeuwen-Snoeks, Lobke and ten Bokkel Huinink, Daan and Sonke, Gabe and Lahuerta, Ainhara and Mann, G. Bruce and Francis, Prudence A. and Richardson, Gary and Malter, Wolfram and van der Wall, Elsken and Aaronson, Neil K. and Senkus, Elzbieta and Urruticoechea, Ander and Zopf, Eva M. and Bloch, Wilhelm and Stuiver, Martijn M. and Wengstrom, Yvonne and Steindorf, Karen and May, Anne M. UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, mireia.pelaez@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2024) Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial. Nature Medicine. ISSN 1078-8956

Text s41591-024-03143-y.pdf Download (3MB)

Abstract

Physical exercise both during and after curative cancer treatment has been shown to reduce side effects. Evidence in the metastatic cancer setting is scarce, and interventions that improve health-related quality of life (HRQOL) are much needed for patients with metastatic breast cancer (MBC). The multinational randomized controlled PREFERABLE-EFFECT trial assessed the effects of exercise on fatigue and HRQOL in patients with MBC. In total, 357 patients with MBC and a life expectancy of ≥6 months but without unstable bone metastases were recruited at eight study centers across five European countries and Australia. Participants were randomly assigned (1:1) to usual care (control group, n = 179) or a 9-month supervised exercise program (exercise group, n = 178). Intervention effects on physical fatigue (European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-FA12 scale) and HRQOL (EORTC QLQ-C30 summary score) were determined by comparing the change from baseline to 3, 6 (primary timepoint) and 9 months between groups using mixed models for repeated measures, adjusted for baseline values of the outcome, line of treatment (first or second versus third or higher) and study center. Exercise resulted in significant positive effects on both primary outcomes. Physical fatigue was significantly lower (−5.3 (95% confidence interval (CI), −10.0 to −0.6), Bonferroni–Holm-adjusted P = 0.027; Cohen's effect size, 0.22) and HRQOL significantly higher (4.8 (95% CI, 2.2–7.4), Bonferroni–Holm-adjusted P = 0.0003; effect size, 0.33) in the exercise group than in the control group at 6 months. Two serious adverse events occurred (that is, fractures), but both were not related to bone metastases. These results demonstrate that supervised exercise has positive effects on physical fatigue and HRQOL in patients with MBC and should be recommended as part of supportive care.

Item Type:	Article
Uncontrolled Keywords:	Breast cancer ; Outcomes research
Subjects:	Subjects > Biomedicine Subjects > Physical Education and Sport
Divisions:	Europe University of Atlantic > Research > Scientific Production
Depositing User:	Sr Bibliotecario
Date Deposited:	16 Sep 2024 10:20
Last Modified:	21 Oct 2024 11:31
URI:	http://repositorio.funiber.org/id/eprint/14209

Actions (login required)

View Item