Upholding or Breaking the Law of Superposition in Pharmacokinetics

Yousef, Malaz and Yáñez, Jaime A. and Löbenberg, Raimar and Davies, Neal M. UNSPECIFIED, jaime.yanez@unini.edu.mx, UNSPECIFIED, UNSPECIFIED (2024) Upholding or Breaking the Law of Superposition in Pharmacokinetics. Biomedicines, 12 (8). p. 1843. ISSN 2227-9059

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Abstract

The law of superposition underpins first-order linear pharmacokinetic relationships. Most drugs, therefore, after a single dose can be described by first-order or linear processes, which can be superposed to understand multiple-dose regimen behavior. However, there are a number of situations where drugs could display behaviors after multiple dosing that leads to capacity-limited or saturation non-linear kinetics and the law of superposition is overruled. This review presents a practical guide to understand the equations and calculations for single and multiple-dosing regimens after intravenous and oral administration. It also provides the pharmaceutical basis for saturation in ADME processes and the consequent changes in the area under the concentration–time curve, which represents drug exposure that can lead to the modulation of efficacy and/or toxic effects. The pharmacokineticist must implicitly understand the principles of superposition, which are a central tenet of drug behavior and disposition during drug development.

Item Type:	Article
Uncontrolled Keywords:	pharmacokinetics; superposition; steady state; linearity; multiple dosing
Subjects:	Subjects > Biomedicine
Divisions:	Ibero-american International University > Research > Scientific Production
Depositing User:	Sr Bibliotecario
Date Deposited:	24 Sep 2024 08:38
Last Modified:	21 Oct 2024 11:34
URI:	http://repositorio.funiber.org/id/eprint/14361

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