Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action

Godos, Justyna and Romano, Giovanni Luca and Laudani, Samuele and Gozzo, Lucia and Guerrera, Ida and Dominguez Azpíroz, Irma and Martínez Díaz, Raquel and Quiles, José L. and Battino, Maurizio and Drago, Filippo and Giampieri, Francesca and Galvano, Fabio and Grosso, Giuseppe UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, irma.dominguez@unini.edu.mx, raquel.martinez@uneatlantico.es, jose.quiles@uneatlantico.es, maurizio.battino@uneatlantico.es, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2024) Flavan-3-ols and Vascular Health: Clinical Evidence and Mechanisms of Action. Nutrients, 16 (15). p. 2471. ISSN 2072-6643

Text nutrients-16-02471.pdf Available under License Creative Commons Attribution. Download (829kB)

Abstract

Cardiovascular diseases (CVDs) are one of the main causes of mortality and morbidity worldwide. A healthy diet rich in plant-derived compounds such as (poly)phenols appears to have a key role in improving cardiovascular health. Flavan-3-ols represent a subclass of (poly)phenols of great interest for their possible health benefits. In this review, we summarized the results of clinical studies on vascular outcomes of flavan-3-ol supplementation and we focused on the role of the microbiota in CVD. Clinical trials included in this review showed that supplementation with flavan-3-ols mostly derived from cocoa products significantly reduces blood pressure and improves endothelial function. Studies on catechins from green tea demonstrated better results when involving healthy individuals. From a mechanistic point of view, emerging evidence suggests that microbial metabolites may play a role in the observed effects. Their function extends beyond the previous belief of ROS scavenging activity and encompasses a direct impact on gene expression and protein function. Although flavan-3-ols appear to have effects on cardiovascular health, further studies are needed to clarify and confirm these potential benefits and the rising evidence of the potential involvement of the microbiota.

Item Type:	Article
Uncontrolled Keywords:	flavan-3-ols; polyphenols; inflammation; vascular; gut microbiota
Subjects:	Subjects > Biomedicine Subjects > Nutrition
Divisions:	Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production Ibero-american International University > Research > Scientific Production Universidad Internacional do Cuanza > Research > Scientific Production University of La Romana > Research > Scientific Production
Depositing User:	Sr Bibliotecario
Date Deposited:	24 Sep 2024 09:42
Last Modified:	24 Sep 2024 09:42
URI:	http://repositorio.funiber.org/id/eprint/14366

Actions (login required)

View Item