Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives

Li, Xiaopeng and Xie, Enjun and Sun, Shumin and Shen, Jie and Ding, Yujin and Wang, Jiaqi and Peng, Xiaoyu and Zheng, Ruting and Farag, Mohamed A. and Xiao, Jianbo UNSPECIFIED (2025) Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives. Journal of Advanced Research. ISSN 20901232

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Abstract

Background: Flavonoids are naturally occurring dietary phytochemicals with significant antioxidant effects aside from several health benefits. People often consume them in combination with other food components. Compiling data establishes a link between bioactive flavonoids and prevention of several diseases in animal models, including cardiovascular diseases, diabetes, gut dysbiosis, and metabolic dysfunction-associated steatotic liver disease (MASLD). However, numerous clinical studies have demonstrated the ineffectiveness of flavonoids contradicting rodent models, thereby challenging the validity of using flavonoids as dietary supplements. Aim of Review: This review provides a clinical perspective to emphasize the effective roles of dietary flavonoids as well as to summarize their specific mechanisms in animals briefly.

Item Type:	Article
Uncontrolled Keywords:	Dietary flavonoids; Metabolism; Metabolic disorder; Health benefits;Clinical evidence
Subjects:	Subjects > Biomedicine Subjects > Nutrition
Divisions:	Europe University of Atlantic > Research > Scientific Production
Depositing User:	Sr Bibliotecario
Date Deposited:	16 Jan 2025 13:12
Last Modified:	16 Jan 2025 13:12
URI:	http://repositorio.funiber.org/id/eprint/16153

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