Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies

Godos, Justyna and Currenti, Walter and Ferri, Raffaele and Lanza, Giuseppe and Caraci, Filippo and Frias-Toral, Evelyn and Guglielmetti, Monica and Ferraris, Cinzia and Lipari, Vivian and Carvajal Altamiranda, Stefanía and Galvano, Fabio and Castellano, Sabrina and Grosso, Giuseppe UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, vivian.lipari@uneatlantico.es, stefania.carvajal@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2025) Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies. Nutrients, 17 (3). p. 529. ISSN 2072-6643

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Abstract

Fasting–feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal timing underscores the importance of maintaining circadian alignment in order to avoid creating a metabolic environment conducive to carcinogenesis following the molecular and systemic disruption of metabolic performance and immune function. The chronicity of such a condition may support the initiation and progression of cancer through a variety of mechanisms, including increased oxidative stress, immune suppression, and the activation of proliferative signaling pathways. This review aims to summarize current evidence from human studies and provide an overview of the potential mechanisms underscoring the role of chrononutrition (including time-restricted eating) on cancer risk. Current evidence shows that the morning chronotype, suggesting an alignment between physiological circadian rhythms and eating timing, is associated with a lower risk of cancer. Also, early time-restricted eating and prolonged nighttime fasting were also associated with a lower risk of cancer. The current evidence suggests that the chronotype influences cancer risk through cell cycle regulation, the modulation of metabolic pathways and inflammation, and gut microbiota fluctuations. In conclusion, although there are no clear guidelines on this matter, emerging evidence supports the hypothesis that the role of time-related eating (i.e., time/calorie-restricted feeding and intermittent/periodic fasting) could potentially lead to a reduced risk of cancer.

Item Type:	Article
Additional Information:	chronotype; sleep; time-restricted eating; circadian rhythm; metabolic dysregulation; gut microbiota; cancer
Subjects:	Subjects > Biomedicine Subjects > Nutrition
Divisions:	Europe University of Atlantic > Research > Scientific Production Fundación Universitaria Internacional de Colombia > Research > Scientific Production Ibero-american International University > Research > Scientific Production Universidad Internacional do Cuanza > Research > Scientific Production University of La Romana > Research > Scientific Production
Depositing User:	Sr Bibliotecario
Date Deposited:	20 Feb 2025 13:12
Last Modified:	20 Feb 2025 13:12
URI:	http://repositorio.funiber.org/id/eprint/16759

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