Zheng, Xuanyu and Huang, Wenqi and Farag, Mohamed A. and Xiao, Jianbo and Li, Chunlin UNSPECIFIED (2025) Intergenerational inheritance of quercetin-induced abnormal immunity in mice. Critical Reviews in Food Science and Nutrition. pp. 1-12. ISSN 1040-8398
Full text not available from this repository.Abstract
Quercetin, a dietary flavonol enriched in food, regulates immune-related models through epigenetic modifications. However, few studies have explored the transmission of regulatory effects across generations to the progeny. Here, we selected Escherichia coli, a conditional pathogen capable of causing gastrointestinal infections or various localized tissue and organ infections under specific conditions, as the pathogenic strain to infect mice. We provide evidence that quercetin can not only induce responsiveness changes against systemic E. coli infection in directly exposed organisms, but also in subsequent generations through the transgenerational inheritance of epigenetic traits. Both parental male mice and their progeny exhibited cellular and phenotypic changes associated with metabolic alterations. Surprisingly, the male and female progeny of mice treated with quercetin (200 mg/kg) for six weeks negatively enhanced the survival rate under systemic E. coli (1 × 108 CFU/mL) infection, concurrent with an increase in bacterial loads in the liver and spleen. Serum TNF-α and IL-1β levels significantly increased post-infection in the progeny. Our results provide the first evidence of the inheritance of immunity driven by quercetin in mammals and the attenuation of protection against bacterial infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Quercetin; intergenerational inheritance; epigenetic; immune function; infection |
| Subjects: | Subjects > Biomedicine Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 24 Mar 2025 09:41 |
| Last Modified: | 24 Mar 2025 09:41 |
| URI: | http://repositorio.funiber.org/id/eprint/17393 |
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