Alvarez-Suarez, José Miguel and Giampieri, Francesca and Cordero, Mario and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Yuliet and Mazzoni, Luca and Afrin, Sadia and Beltrán-Ayala, Pablo and González-Paramás, Ana María and Santos-Buelga, Celestino and Varela-Lopez, Alfonso and Quiles, José Luis and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2016) Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing. Journal of Functional Foods, 25. pp. 38-49. ISSN 1756-4646
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Abstract
Excessive amounts of free radicals are deleterious for cells, resulting in cell damage, affecting the wound healing process and causing premature ageing or even neoplastic transformation. Here the capacity of Manuka honey (MH) to protect against oxidative damage and improve the process of skin wound healing was investigated. Up to 16 compounds were identified in MH, with leptosin derivatives and methyl syringate as the major ones. MH protected against apoptosis, intracellular ROS production, and lipid and protein oxidative damage. MH also protected mitochondrial functionality, promoted cell proliferation and activated the AMPK/Nrf2/ARE signalling pathway, as well as the expression of the antioxidant enzymes such as SOD and CAT. Here we describe for the first time that one of the possible mechanisms by which MH exhibits its ability to promote wound healing could be due to its capacity to improve the antioxidant response by activating AMPK phosphorylation and the ARE response.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Manuka honey, ROSAMPK, Nrf2Wound healing |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 11:23 |
| Last Modified: | 03 Mar 2022 11:27 |
| URI: | http://repositorio.funiber.org/id/eprint/176 |
Available Versions of this Item
- Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing. (deposited 20 May 2021 11:23) [Currently Displayed]
Commentary/Response Threads
- Alvarez-Suarez, José Miguel and Giampieri, Francesca and Cordero, Mario and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Yuliet and Mazzoni, Luca and Afrin, Sadia and Beltrán-Ayala, Pablo and González-Paramás, Ana María and Santos-Buelga, Celestino and Varela-Lopez, Alfonso and Quiles, José Luis and Battino, Maurizio Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing. (deposited 20 May 2021 11:23) [Currently Displayed]
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