Effect of Supplementation with Probiotics in Patients with Schizophrenia: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Li, Lu and Du, Fengqi and Liu, Xilong and Song, Mengyao and Grosso, Giuseppe and Battino, Maurizio and Boesch, Christine and Li, He and Liu, Xinqi UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2025) Effect of Supplementation with Probiotics in Patients with Schizophrenia: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Foods, 14 (10). p. 1773. ISSN 2304-8158

Text foods-14-01773-v2.pdf Available under License Creative Commons Attribution. Download (8MB)

Abstract

Supplementation with probiotics seems to confer protective effects in individuals with schizophrenia (SZ), although available results are inconclusive. The aim of this study was to systematically review existing randomized clinical trials (RCTs) to critically assess the effect of probiotics on psychiatric symptoms, anthropometric indicators, lipid profiles, glycemic indices, inflammation, and oxidative stress in adults with SZ. A systematic search was conducted in four databases from inception until January 2025. Six RCTs were included in the quantitative analysis that demonstrated beneficial effects of probiotics on SZ severity determined via the Positive and Negative Syndrome Scale (PANSS), with significant reductions in PANSS (MD = −0.50, p = 0.001), PANSS Negative (MD = −0.31, p = 0.050), and PANSS General scores (MD = −0.33, p = 0.036), alongside reductions in body weight (MD = −0.92, p = 0.000), body mass index (MD = −0.53, p = 0.016), and total cholesterol (SMD = −0.34, p = 0.005). Furthermore, probiotic interventions reduced baseline glucose (SMD = −0.59, p = 0.000), insulin (MD = −0.68, p = 0.000), and measures of insulin sensitivity/resistance and significantly improved biomarkers of inflammation and oxidative stress. To summarize, this meta-analysis suggests that probiotics may confer beneficial effects in patients with SZ through improving psychiatric symptoms as well as markers of body weight, lipid and glucose metabolism, inflammation, and oxidative stress.

Item Type:	Article
Uncontrolled Keywords:	probiotics; psychiatric symptom; lipid profile; glycemic indices; inflammation; oxidative stress; meta-analysis
Subjects:	Subjects > Biomedicine Subjects > Psychology Subjects > Nutrition
Divisions:	Europe University of Atlantic > Research > Scientific Production
Depositing User:	Sr Bibliotecario
Date Deposited:	17 Jun 2025 09:29
Last Modified:	17 Jun 2025 09:29
URI:	http://repositorio.funiber.org/id/eprint/17811

Actions (login required)

View Item