Rezabakhsh, Aysa and Safaei, Nasser and Nabavi, Seyed Mohammad and Roosta, Yousef and Giampieri, Francesca and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2025) Anti-atherogenic immune checkpoint TIM-3 as a promising pharmacologic target toward ischemic heart diseases: a prospective review. Molecular Biology Reports, 52 (1). ISSN 0301-4851
Abstract
Recently, immunogene therapy has been of great interest in cardiovascular diseases. In this regard, various immune checkpoint inhibitors (ICIs) are identified to have a crucial role in regulating inflammatory responses. The T-cell immunoglobulin and mucin-domain containing molecule-3 (TIM-3, CD366), a relatively newly discovered group of molecules with a conserved structure, has emerged as a critical immune checkpoint with significant regulatory roles in cardiovascular inflammation and atherosclerosis. This prospective review explores the importance of TIM-3 in modulating immune responses relevant to ischemic heart diseases (IHD), highlighting its interactions with inflammatory pathways such as Toll-like receptor-4 (TLR-4). TIM-3, predominantly expressed on T cells, dendritic cells, and monocytes, acts as an inhibitory receptor that quenches pro-inflammatory signaling, particularly upon binding to ligands like galectin-9. Noteworthy, recent evidence suggests that TIM-3 deficiency or dysregulation can exacerbate inflammatory cascades, contributing to the progression of IHD and related complications. Here, the therapeutic potential of targeting TIM-3 for the management of IHD, especially in the settings of systemic inflammation and post-operative complications, has been discussed. By elucidating the molecular mechanisms and translational prospects of TIM-3 modulation, this work proposes new avenues for immunotherapeutic intervention in cardiovascular disease and post-operative SIRS, warranting further research in clinical trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Immune checkpoint inhibitors; Ischemic heart diseases Inflammatory heart disease; Systemic inflammatory reaction syndrome (SIRS); T-cell immunoglobulin and mucin domain 3 |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Articles and books |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 05 Sep 2025 10:07 |
| Last Modified: | 05 Sep 2025 10:07 |
| URI: | https://repositorio.funiber.org/id/eprint/17835 |
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