Cassotta, Manuela and Armas Diaz, Yasmany and Cianciosi, Danila and Yang, Bei and Qi, Zexiu and Chen, Ge and Gracia Villar, Santos and Dzul López, Luis Alonso and Grosso, Giuseppe and Quiles, José L. and Xiao, Jianbo and Battino, Maurizio and Giampieri, Francesca manucassotta@gmail.com, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, luis.dzul@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, francesca.giampieri@uneatlantico.es (2025) Single-cell omics for nutrition research: an emerging opportunity for human-centric investigations. Critical Reviews in Food Science and Nutrition. pp. 1-15. ISSN 1040-8398
Full text not available from this repository.Abstract
Understanding how dietary compounds affect human health is challenged by their molecular complexity and cell-type–specific effects. Conventional multi-cell type (bulk) analyses obscure cellular heterogeneity, while animal and standard in vitro models often fail to replicate human physiology. Single-cell omics technologies—such as single-cell RNA sequencing, as well as single-cell–resolved proteomic and metabolomic approaches—enable high-resolution investigation of nutrient–cell interactions and reveal mechanisms at a single-cell resolution. When combined with advanced human-derived in vitro systems like organoids and organ-on-chip platforms, they support mechanistic studies in physiologically relevant contexts. This review outlines emerging applications of single-cell omics in nutrition research, emphasizing their potential to uncover cell-specific dietary responses, identify nutrient-sensitive pathways, and capture interindividual variability. It also discusses key challenges—including technical limitations, model selection, and institutional biases—and identifies strategic directions to facilitate broader adoption in the field. Collectively, single-cell omics offer a transformative framework to advance human-centric nutrition research.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Nutrition research; organoids; personalized nutrition; 3Rs; single-cell omics |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production Universidad Internacional do Cuanza > Research > Scientific Production University of La Romana > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 03 Nov 2025 11:40 |
| Last Modified: | 03 Nov 2025 11:40 |
| URI: | http://repositorio.funiber.org/id/eprint/17867 |
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