Wu, Qian and Zhang, Xingyu and Zhang, Jingjia and Huang, Gaohui and Zhou, Chen and Li, Chunlin and Huang, Xiaojun and Xiao, Jianbo and Feng, Nianjie and She, Yuanbin UNSPECIFIED (2026) Constraint of Lignin–Carbohydrate Complex Orchestrated on Polyphenol in Oil–Water Interface Targeting Ulcerative Colitis Therapy. Advanced Science. ISSN 2198-3844
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Advanced Science - 2026 - Wu - Constraint of Lignin Carbohydrate Complex Orchestrated on Polyphenol in Oil Water Interface.pdf Download (12MB) |
Abstract
The therapeutic potential of polyphenols in ulcerative colitis (UC), mediated through immune modulation and gut microbiota homeostasis. To enhance the oral bioavailability of polyphenols, we architected a colon–targeted W1/O/W2 emulsion system featuring a rationally designed lignin–carbohydrate complex (LCC) as a dual–functional emulsifier system for the first time. Based on the innate structural duality of LCC, which comprising hydrophobic lignin and hydrophilic carbohydrates, we employed LCC for O/W emulsifier. This inherent amphiphilicity was further engineered via laccase–mediated grafting of isovanillin, yielding a modified LCC with tailored lipophilicity for effective W/O interfacial stabilization. The W1/O/W2 emulsion ensured the stability of the encapsulated polyphenols with divergent polarity but also enabled pH–responsive payload release under colonic conditions (pH >7.0). In DSS–induced colitis, the system demonstrated a synergistic effect, the LCC itself acted as a prebiotic to modulate the gut microbiota, specifically enriching short chain fatty acid–producing bacteria, while the released polyphenols reinforced the intestinal barrier, which collectively accelerated mucosal healing. This research proposes a carbon–neutral therapeutic strategy for colitis, not only establishing a proof–of–concept for replacing synthetic emulsifiers with engineered biomass, but also as a multi–functional platform to stabilize colon–targeted co–delivery system and microbiome regulation in colitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | intestinal microflora| lignin–carbohydrate complex| polyphenols| ulcerative colitis| W 1 /O/W 2 emulsion |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 13 Mar 2026 13:58 |
| Last Modified: | 13 Mar 2026 13:58 |
| URI: | http://repositorio.funiber.org/id/eprint/27827 |
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