Perumprath, Aneesh S. and Sagayam, Kulandairaj Martin and Ansarullah, Syed Immamul and Khan, Shafat and Alshmrany, Sami and Amin, Farhan and Díez, Isabel de la Torre and Garat de Marin, Mirtha Silvana and Silva Alvarado, Eduardo René UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, silvana.marin@uneatlantico.es, eduardo.silva@funiber.org (2026) A Multilevel Deep Learning Model for Automated Brain Tumor Segmentation Using Magnetic Resonance Images. Diagnostics, 16 (14). p. 2259. ISSN 2075-4418
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Abstract
Background/Objectives: Brain tumor segmentation from magnetic resonance imaging (MRI) plays an important role in clinical assessment and treatment planning. However, accurate segmentation remains challenging because of the complex anatomical structure of the brain, variations in tumor size and shape, and the imbalance between tumor and non-tumor regions in MRI datasets. These challenges highlight the need for reliable automated segmentation methods. Methods: This study proposes a multilevel deep learning model for automated brain tumor segmentation using MRI images. The BraTS dataset was used for model development and evaluation. To address class imbalance, a modified Synthetic Minority Oversampling Technique (SMOTE) was incorporated during preprocessing. A Multilevel Architecture-Based Modified U-Net was then employed to learn multiscale spatial features and generate pixel-wise tumor segmentation. The proposed framework was evaluated using the Dice coefficient, Jaccard coefficient, Matthews Correlation Coefficient (MCC), and accuracy. Results: The experimental results demonstrate that the proposed model consistently outperformed the Berkeley Wavelet Transform (BWT)-based method and the conventional U-Net across different tumor grades. Higher Dice, Jaccard, and MCC values indicate improved agreement between the predicted segmentation and the expert-annotated ground truth masks, demonstrating more accurate and consistent tumor delineation. Conclusions: The proposed multilevel deep learning model provides an effective framework for automated brain tumor segmentation from MRI images. By combining imbalance-aware preprocessing with a lightweight Modified U-Net architecture, the proposed method improves segmentation performance while maintaining a relatively simple network design. Future work will focus on validating the proposed framework using external clinical datasets and comparing it with recent state-of-the-art segmentation models.
| Item Type: | Article |
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| Uncontrolled Keywords: | deep learning; brain; segmentation; detection; multilevel architecture-based modified U-Net |
| Subjects: | Subjects > Engineering |
| Divisions: | Europe University of Atlantic > Research > Articles and books Ibero-american International University > Research > Articles and Books |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 03 Sep 2026 07:40 |
| Last Modified: | 03 Sep 2026 07:40 |
| URI: | https://repositorio.funiber.org/id/eprint/29654 |
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