Letter: cfDNA testing in recurrent pregnancy loss: a new step in the right way but still raw for the clinical area

Marcos Rodríguez, Ana Teresa and Navarro-Pando, José Manuel anateresa.marcos@uneatlantico.es, jose.navarro@uneatlantico.es (2020) Letter: cfDNA testing in recurrent pregnancy loss: a new step in the right way but still raw for the clinical area. Human Reproduction, 36 (3). pp. 827-829. ISSN 0268-1161

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Abstract

Sir, In their recently published study, Yaron et al. (2020) expose an interesting strategy based in cfDNA testing (cfDNA-T) which could serve as an alternative to cytogenetic analysis in products of conceptions in recurrent pregnancy loss and could guide further management of this medical topic; however, in our opinion, some important aspects should be considered. Firstly, Illanes et al. (2007) found that cfDNA concentration in the maternal blood can be detected from Week 4 of gestation but it is only reliable from Week 7. However, others authors’ experience could be different. Clark-Ganheart et al. (2015) recommend cfDNA analysis only after 8 weeks of gestation. Zeevi et al. (2018) reported that aneuploidy screening by cfDNA is not generally accurate before Week 8, leading to a period in pregnancy (namely, Weeks 4 through 8) during which assessment of the genetic status of the embryo is not generally feasible. Galeva et al....

Item Type: Article
Subjects: Subjects > Biomedicine
Divisions: Europe University of Atlantic > Research > Scientific Production
Depositing User: Sr Bibliotecario
Date Deposited: 08 Feb 2022 11:45
Last Modified: 30 Jun 2023 10:19
URI: http://repositorio.funiber.org/id/eprint/510

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