Ramos-Vivas, José and Superio, Joshua and Galindo-Villegas, Jorge and Acosta, Félix jose.ramos@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Phage Therapy as a Focused Management Strategy in Aquaculture. International Journal of Molecular Sciences, 22 (19). p. 10436. ISSN 1422-0067
|
Text
ijms-22-10436.pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Therapeutic bacteriophages, commonly called as phages, are a promising potential alternative to antibiotics in the management of bacterial infections of a wide range of organisms including cultured fish. Their natural immunogenicity often induces the modulation of a variated collection of immune responses within several types of immunocytes while promoting specific mechanisms of bacterial clearance. However, to achieve standardized treatments at the practical level and avoid possible side effects in cultivated fish, several improvements in the understanding of their biology and the associated genomes are required. Interestingly, a particular feature with therapeutic potential among all phages is the production of lytic enzymes. The use of such enzymes against human and livestock pathogens has already provided in vitro and in vivo promissory results. So far, the best-understood phages utilized to fight against either Gram-negative or Gram-positive bacterial species in fish culture are mainly restricted to the Myoviridae and Podoviridae, and the Siphoviridae, respectively. However, the current functional use of phages against bacterial pathogens of cultured fish is still in its infancy. Based on the available data, in this review, we summarize the current knowledge about phage, identify gaps, and provide insights into the possible bacterial control strategies they might represent for managing aquaculture-related bacterial diseases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aquaculture; Bacteriophages; Disease management; Fish; Immunology; Lytic enzymes; Pathogens |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 08 Mar 2022 13:54 |
| Last Modified: | 07 Jul 2023 10:14 |
| URI: | http://repositorio.funiber.org/id/eprint/523 |
Actions (login required)
 |
View Item |
