Morales-Navas, Miguel and Castaño-Castaño, Sergio and Pérez-Fernández, Cristian and Sánchez-Gil, Ainhoa and Teresa Colomina, María and Leinekugel, Xavier and Sánchez-Santed, Fernando UNSPECIFIED, sergio.castano@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2020) Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats. International Journal of Environmental Research and Public Health, 17 (17). p. 6376. ISSN 1660-4601
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Abstract
Background: In recent years, ultrasonic vocalizations (USV) in pups has become established as a good tool for evaluating behaviors related to communication deficits and emotional states observed in autism spectrum disorder (ASD). Prenatal valproic acid (VPA) exposure leads to impairments and social behavior deficits associated with autism, with the effects of VPA being considered as a reliable animal model of ASD. Some studies also suggest that prenatal exposure to chlorpyrifos (CPF) could enhance autistic-like behaviors. Methods: In order to explore these similarities, in the present study we tested whether prenatal exposure to CPF at GD12.5–14.5 produces effects that are comparable to those produced by prenatal VPA exposure at GD12.5 in infant Wistar rats. Using Deep Squeek software, we evaluated total number of USVs, latency to the first call, mean call duration, principal frequency peak, high frequency peak, and type of calls. Results: Consistent with our hypothesis, we found that exposure to both CPF and VPA leads to a significantly smaller number of calls along with a longer latency to produce the first call. No significant effects were found for the remaining dependent variables. Conclusions: These results suggest that prenatal exposure to CPF could produce certain behaviors that are reminiscent of those observed in ASD patients
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | autistic spectrum disorder; ultrasonic vocalizations; chlorpyrifos; valproic acid; prenatal exposure; autism; organophosphates |
| Subjects: | Subjects > Biomedicine Subjects > Psychology |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 09 Mar 2022 11:43 |
| Last Modified: | 03 Jul 2023 10:37 |
| URI: | http://repositorio.funiber.org/id/eprint/528 |
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