González‐Dominguez, Alvaro and Montañez, Raúl and Castejón‐Vega, Beatriz and Nuñez‐Vasco, Jéssica and Lendines‐Cordero, Débora and Wang, Chun and Mbalaviele, Gabriel and Navarro-Pando, José Manuel and Alcocer‐Gómez, Elísabet and Cordero, Mario D UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.navarro@uneatlantico.es, UNSPECIFIED, UNSPECIFIED (2021) Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria. EMBO Molecular Medicine, 13 (10). ISSN 1757-4676
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EMBO Mol Med - 2021 - Gonz lez‐Dominguez - Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of (1).pdf - Published Version Available under License Creative Commons Attribution. Download (966kB) | Preview |
Abstract
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome pathway in HGPS skin fibroblasts, an outcome that was associated with morphological changes of the nuclei of the cells. Lymphoblasts from HGPS patients also showed increased basal levels of NLRP3 and caspase 1. Consistent with these results, the expression of caspase 1 and Nlrp3, but not of the other inflammasome receptors was higher in the heart and liver of Zmpste24−/− mice, which phenocopy the human disease. These data were further corroborated in LmnaG609G/G609G mice, another HGPS animal model. We also showed that pharmacological inhibition of the NLRP3 inflammasome by its selective inhibitor, MCC950, improved cellular phenotype, significantly extended the lifespan of progeroid animals, and reduced inflammasome-dependent inflammation. These findings suggest that inhibition of the NLRP3 inflammasome is a potential therapeutic approach for the treatment of HGPS.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Aging; NLRP3inflammasome; Progeria |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 11 Mar 2022 09:12 |
| Last Modified: | 05 Jul 2023 10:19 |
| URI: | http://repositorio.funiber.org/id/eprint/544 |
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