Cianciosi, Danila and Forbes-Hernandez, Tamara Y. and Alvarez-Suarez, José M. and Ansary, Johura and Quinzi, Denise and Amici, Adolfo and Navarro-Hortal, María D. and Esteban-Muñoz, Adelaida and Quiles, José Luis and Battino, Maurizio and Giampieri, Francesca UNSPECIFIED (2021) Anti-inflammatory activities of Italian Chestnut and Eucalyptus honeys on murine RAW 264.7 macrophages. Journal of Functional Foods, 87. p. 104752. ISSN 17564646
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Abstract
The aim of this study was to evaluate for the first time the anti-inflammatory effects of chestnut (Castanea sativa) and Eucalyptus (Eucalyptus occidentalis) honeys collected in Italy on murine RAW 264.7 macrophages stressed with the bacterial endotoxin lipopolysaccharide (LPS). Pre-treatment with the two honeys markedly decreased apoptosis and stimulated wound healing in macrophages stressed with LPS, where they also reduced the intracellular levels of ROS and nitrite. Additionally, treatment with LPS decreased the levels of glutathione and suppressed the antioxidant enzyme activities, which were significantly (p < 0.05) increased in the presence of the two honeys, through the modulation of Nrf2 expression; in LPS-stressed macrophages, Chestnut or Eucalyptus honeys protected against inflammation by regulating the main inflammatory biomarkers, including TNF-α, IL-10 and iNOS, through the decrease of NF-кB expression. Finally, they improved mitochondrial respiration and the main related parameters.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Honey; Inflammation; Mitochondrial respiration; Apoptosis; Wound healing; Antioxidant enzymes |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 13 Apr 2022 12:22 |
| Last Modified: | 04 Jul 2023 08:55 |
| URI: | http://repositorio.funiber.org/id/eprint/627 |
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