Varela-López, Alfonso and Romero-Márquez, José M. and Navarro-Hortal, María D. and Ramirez-Tortosa, César L. and Battino, Maurizio and Forbes-Hernández, Tamara Y. and Quiles, José L. UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, jose.quiles@uneatlantico.es (2023) Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models. Experimental Gerontology, 178. p. 112221. ISSN 05315565
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Abstract
The rise of life expectancy in current societies is not accompanied, to date, by a similar increase in healthspan, which represents a great socio-economic problem. It has been suggested that aging can be manipulated and then, the onset of all age-associated chronic disorders can be delayed because these pathologies share age as primary underlying risk factor. One of the most extended ideas is that aging is consequence of the accumulation of molecular damage. According to the oxidative damage theory, antioxidants should slow down aging, extending lifespan and healthspan. The present review analyzes studies evaluating the effect of dietary antioxidants on lifespan of different aging models and discusses the evidence on favor of their antioxidant activity as anti-aging mechanisms. Moreover, possible causes for differences between the reported results are evaluated.
| Item Type: | Article |
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| Uncontrolled Keywords: | Aging; Ageing; Longevity; Bioactive compounds; Nutrient-sensing pathways; Hormesis |
| Subjects: | Subjects > Biomedicine Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 31 May 2023 07:51 |
| Last Modified: | 21 Oct 2024 12:46 |
| URI: | http://repositorio.funiber.org/id/eprint/7347 |
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