Alvarez-Suarez, José M. and Giampieri, Francesca and Gasparrini, Massimiliano and Mazzoni, Luca and Forbes-Hernández, Tamara Y. and Afrin, Sadia and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@uneatlantico.es, UNSPECIFIED, maurizio.battino@uneatlantico.es (2018) Guava (Psidium guajava L. cv. Red Suprema) Crude Extract Protect Human Dermal Fibroblasts against Cytotoxic Damage Mediated by Oxidative Stress. Plant Foods for Human Nutrition, 73 (1). pp. 18-24. ISSN 0921-9668
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Abstract
We analyzed guava fruits (Psidium guajava L. cv. Red Suprema) from Cuba to determine their chemical composition, total antioxidant capacity, as well as their protective effect against oxidative damage using an in vitro model of human dermal fibroblasts. The guava fruit is a natural source of bioactive compounds, such as polyphenols, vitamin C, folates and beta carotenes with proven health benefits. Human dermal fibroblasts were pre-incubated with different concentrations of guava crude extract and then subjected to oxidative stress using the AAPH stressor. The number of apoptotic and dead cells, as well as the markers of oxidative damage such as lipid and protein oxidation significantly decreased when cells were pre-incubated with guava crude extract and then exposed to the stressor. The activity of antioxidant enzymes also improved when cells were pre-incubated with guava crude extract in comparison to cells subjected to stress without prior pre-incubation with the guava extract. The results obtained in this study highlight the health benefits of guava regarding oxidative stress, proving it to be an important source of bioactive compounds associated with important biological properties.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Guava fruit; Antioxidant capacity; Human dermal fibroblast; Oxidative stress. |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:38 |
| Last Modified: | 02 Mar 2022 15:25 |
| URI: | http://repositorio.funiber.org/id/eprint/83 |
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- Guava (Psidium guajava L. cv. Red Suprema) Crude Extract Protect Human Dermal Fibroblasts against Cytotoxic Damage Mediated by Oxidative Stress. (deposited 20 May 2021 10:38) [Currently Displayed]
Commentary/Response Threads
- Alvarez-Suarez, José M. and Giampieri, Francesca and Gasparrini, Massimiliano and Mazzoni, Luca and Forbes-Hernández, Tamara Y. and Afrin, Sadia and Battino, Maurizio Guava (Psidium guajava L. cv. Red Suprema) Crude Extract Protect Human Dermal Fibroblasts against Cytotoxic Damage Mediated by Oxidative Stress. (deposited 20 May 2021 10:38) [Currently Displayed]
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