Chen, Lei and Teng, Hui and Jia, Zhen and Battino, Maurizio and Miron, Anca and Yu, Zhiling and Cao, Hui and Xiao, Jianbo UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2018) Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence. Critical Reviews in Food Science and Nutrition, 58 (17). pp. 2908-2924. ISSN 1040-8398
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Abstract
Dietary flavonoids, which occur in many plant foods, are considered as the most active constituents among the plant-derived ones in vitro and in vivo. To date, many studies have addressed the anti-inflammatory activity of flavonoids. However, their considerable structural diversity and in vivo bioavailability make them able to modulate different signaling pathways. The present review attempted to summarize and highlight a broad range of inflammation-associated signaling pathways modulated by flavonoids. Finally, based on the current scientist's literature, structure-activity relationships were concluded. Dietary flavonoids have the ability to attenuate inflammation by targeting different intracellular signaling pathways triggered by NF-κB, AP-1, PPAR, Nrf2, and MAPKs. Identification of the main structural features required for the modulation of these inflammation-related pathways (hydroxylation pattern, C2=C3 double bond) have an important role to play in the development of new anti-inflammatory drugs.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Flavonoids; Inflammation; Intracellular signaling pathways; Strectyre-activity relationship. |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:40 |
| Last Modified: | 02 Mar 2022 15:19 |
| URI: | http://repositorio.funiber.org/id/eprint/85 |
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- Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence. (deposited 20 May 2021 10:40) [Currently Displayed]
Commentary/Response Threads
- Chen, Lei and Teng, Hui and Jia, Zhen and Battino, Maurizio and Miron, Anca and Yu, Zhiling and Cao, Hui and Xiao, Jianbo Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence. (deposited 20 May 2021 10:40) [Currently Displayed]
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