Alvarez-Suarez, José M. and Carrillo-Perdomo, Estefanía and Aller, Angel and Giampieri, Francesca and Gasparrini, Massimiliano and González-Pérez, Lien and Beltrán-Ayala, Pablo and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Anti-inflammatory effect of Capuli cherry against LPS-induced cytotoxic damage in RAW 264.7 macrophages. Food and Chemical Toxicology, 102. pp. 46-52. ISSN 0278-6915
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Abstract
Capuli cherry (Prunus serotina Ehr. subsp. capuli (Cav.) McVaugh) fruits from the inter-Andean region of Ecuador were analysed to determine their bioactive compounds content, total antioxidant capacity, radical scavenging activity and their anti-inflammatory and protective effects against the cytotoxic damage mediated by lipopolysaccharide (LPS) in RAW 264.7 macrophages. Capuli fruits proved to be a natural source of bioactive compounds such as anthocyanins, vitamin C and β-carotene as well as to present an important total antioxidant capacity and radical scavenging activities. RAW 264.7 macrophages were incubated with different concentration of Capuli crude extract and subsequently activated by LPS to determine the markers related to oxidative damage and the proinflammatory cytokine production. The markers of oxidative damage, nitrite levels, the interleukin 1β messenger RNA levels and the tumor necrosis factor α mRNA levels and secretion were significantly decreased after the pre-incubated with Capuli extract and subsequently stimulated with LPS. In summary, Capuli extract attenuated the LPS-induced damage in RAW 264.7 macrophages due to its antioxidant and anti-inflammatory properties, showing that Capuli fruits may represent a relevant source of bioactive compounds with promising benefits for human health.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Prunus serotina; Capuli cherry; Antioxidant capacity; Oxidative stress; Inflammation. |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:29 |
| Last Modified: | 02 Mar 2022 15:11 |
| URI: | http://repositorio.funiber.org/id/eprint/88 |
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- Anti-inflammatory effect of Capuli cherry against LPS-induced cytotoxic damage in RAW 264.7 macrophages. (deposited 20 May 2021 10:29) [Currently Displayed]
Commentary/Response Threads
- Alvarez-Suarez, José M. and Carrillo-Perdomo, Estefanía and Aller, Angel and Giampieri, Francesca and Gasparrini, Massimiliano and González-Pérez, Lien and Beltrán-Ayala, Pablo and Battino, Maurizio Anti-inflammatory effect of Capuli cherry against LPS-induced cytotoxic damage in RAW 264.7 macrophages. (deposited 20 May 2021 10:29) [Currently Displayed]
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