Teng, Hui and Lin, Qiyang and Li, Kang and Yuan, Benyao and Song, Hongbo and Peng, Hongquan and Yi, Lunzhao and Wei, Ming-Chi and Yang, Yu-Chiao and Battino, Maurizio and Cespedes Acuña, Carlos L. and Chen, Lei and Xiao, Jianbo UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2017) Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents. Food and Chemical Toxicology, 110. pp. 418-424. ISSN 0278-6915
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Abstract
Raspberry seed is a massive byproduct of raspberry juice and wine but usually discarded. The present study employed a microwave-assisted method for extraction of raspberry seed oil (RSO). The results revealed that omega-6 fatty acids (linoleic acid and γ-linolenic acid) were the major constituents in RSO. Cellular antioxidant enzyme activity such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in HepG2 cells treated with RSO. Induction of the synthesis of several antioxidants in H2O2-exposed HepG2 cells was found. RSO increased the enzyme activity of SOD, CAT, and GPx in H2O2-exposed HepG2. Furthermore, RSO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (c-JNK) and extracellular signal-regulated kinase (ERK). Taken together, the possible mechanisms to increase antioxidant enzyme activities in HepG2 may through the suppression of ERK and JNK phosphorylation. Raspberry seed oil exhibited good effects on the activities of the intracellular antioxidant enzymes and seems to protect the liver from oxidative stress through the inhibition of MAPKs.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Raspberry seeds; Fatty acids; Extraction; Antioxidant enzyme; Hepatoprotection |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:30 |
| Last Modified: | 02 Mar 2022 15:04 |
| URI: | http://repositorio.funiber.org/id/eprint/90 |
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- Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents. (deposited 20 May 2021 10:30) [Currently Displayed]
Commentary/Response Threads
- Teng, Hui and Lin, Qiyang and Li, Kang and Yuan, Benyao and Song, Hongbo and Peng, Hongquan and Yi, Lunzhao and Wei, Ming-Chi and Yang, Yu-Chiao and Battino, Maurizio and Cespedes Acuña, Carlos L. and Chen, Lei and Xiao, Jianbo Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents. (deposited 20 May 2021 10:30) [Currently Displayed]
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