Bullón, Pedro and Román-Malo, Lourdes and Marín-Aguilar, Fabiola and Alvarez-Suarez, José Miguel and Giampieri, Francesca and Battino, Maurizio and Cordero, Mario D. UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, josemanuel.alvarez@unini.edu.mx, UNSPECIFIED, maurizio.battino@uneatlantico.es, UNSPECIFIED (2015) Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement. Pharmacological Research, 91. pp. 1-8. ISSN 10436618
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Abstract
Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ10 than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ10 improved mitochondrial biogenesis by activating PGC-1α and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Porphyromonas gingivalis; Lipopolysaccharide; Coenzyme Q10; N-acetylcysteine; Mitochondria |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:20 |
| Last Modified: | 02 Mar 2022 14:29 |
| URI: | http://repositorio.funiber.org/id/eprint/98 |
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- Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement. (deposited 20 May 2021 10:20) [Currently Displayed]
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- Bullón, Pedro and Román-Malo, Lourdes and Marín-Aguilar, Fabiola and Alvarez-Suarez, José Miguel and Giampieri, Francesca and Battino, Maurizio and Cordero, Mario D. Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement. (deposited 20 May 2021 10:20) [Currently Displayed]
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