Persano, Luca and Zagoura, Dimitra and Louisse, Jochem and Pistollato, Francesca UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.pistollato@uneatlantico.es (2015) Role of Environmental Chemicals, Processed Food Derivatives, and Nutrients in the Induction of Carcinogenesis. Stem Cells and Development, 24 (20). pp. 2337-2352. ISSN 1547-3287
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Abstract
In recent years it has been hypothesized that cancer stem cells (CSCs) are the actual driving force of tumor formation, highlighting the need to specifically target CSCs to successfully eradicate cancer growth and recurrence. Particularly, the deregulation of physiological signaling pathways controlling stem cell proliferation, self-renewal, differentiation, and metabolism is currently considered as one of the leading determinants of cancer formation. Given their peculiar, slow-dividing phenotype and their ability to respond to multiple microenvironmental stimuli, stem cells appear to be more susceptible to genetic and epigenetic carcinogens, possibly undergoing mutations resulting in tumor formation. In particular, some animal-derived bioactive nutrients and metabolites known to affect the hormonal milieu, and also chemicals derived from food processing and cooking, have been described as possible carcinogenic factors. Here, we review most recent literature in this field, highlighting how some environmental toxicants, some specific nutrients and their secondary products can induce carcinogenesis, possibly impacting stem cells and their niches, thus causing tumor growth.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:21 |
| Last Modified: | 02 Mar 2022 14:25 |
| URI: | http://repositorio.funiber.org/id/eprint/99 |
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- Role of Environmental Chemicals, Processed Food Derivatives, and Nutrients in the Induction of Carcinogenesis. (deposited 20 May 2021 10:21) [Currently Displayed]
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- Persano, Luca and Zagoura, Dimitra and Louisse, Jochem and Pistollato, Francesca Role of Environmental Chemicals, Processed Food Derivatives, and Nutrients in the Induction of Carcinogenesis. (deposited 20 May 2021 10:21) [Currently Displayed]
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