Inhibition of the NLRP3 inflammasome prevents ovarian aging

Navarro-Pando, José Manuel and Alcocer-Gómez, Elísabet and Castejón-Vega, Beatriz and Navarro-Villarán, Elena and Condés-Hervás, Mónica and Mundi-Roldan, María and Muntané, Jordi and Pérez-Pulido, Antonio J. and Bullon, Pedro and Wang, Chun and Hoffman, Hal M. and Sanz, Alberto and Mbalaviele, Gabriel and Ryffel, Bernhard and Cordero, Mario D. jose.navarro@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, monica.condes@uneatlantico.es, maria.mundi@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, mario.cordero@uneatlantico.es (2021) Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science Advances, 7 (1). eabc7409. ISSN 2375-2548

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Abstract

Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3−/− mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility.

Item Type:	Article
Commentary on:	Eprints 0 not found.
Subjects:	Subjects > Biomedicine
Divisions:	Europe University of Atlantic > Research > Scientific Production
SWORD Depositor:	Users 0 not found.
Depositing User:	Sr Bibliotecario
Date Deposited:	20 May 2021 11:09
Last Modified:	05 Jul 2023 12:56
URI:	http://repositorio.funiber.org/id/eprint/107

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• Inhibition of the NLRP3 inflammasome prevents ovarian aging. (deposited 20 May 2021 11:09) [Currently Displayed]

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• Navarro-Pando, José Manuel and Alcocer-Gómez, Elísabet and Castejón-Vega, Beatriz and Navarro-Villarán, Elena and Condés-Hervás, Mónica and Mundi-Roldan, María and Muntané, Jordi and Pérez-Pulido, Antonio J. and Bullon, Pedro and Wang, Chun and Hoffman, Hal M. and Sanz, Alberto and Mbalaviele, Gabriel and Ryffel, Bernhard and Cordero, Mario D. Inhibition of the NLRP3 inflammasome prevents ovarian aging. (deposited 20 May 2021 11:09) [Currently Displayed]

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