Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration

Rivas-García, Lorenzo and Quiles, José L. and Varela-López, Alfonso and Giampieri, Francesca and Battino, Maurizio and Bettmer, Jörg and Montes-Bayón, María and Llopis, Juan and Sánchez-González, Cristina UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration. Pharmaceutics, 13 (1). p. 90. ISSN 1999-4923

Preview

Text pharmaceutics-13-00090.pdf - Published Version Available under License Creative Commons Attribution. Download (4MB) | Preview

Abstract

The application of metallic nanoparticles (materials with size at least in one dimension ranging from 1 to 100 nm) as a new therapeutic tool will improve the diagnosis and treatment of diseases. The mitochondria could be a therapeutic target to treat pathologies whose origin lies in mitochondrial dysfunctions or whose progression is dependent on mitochondrial function. We aimed to study the subcellular distribution of 2-4 nm iron nanoparticles and its effect on mitochondrial DNA (mtDNA), mitochondrial function, and autophagy in colorectal cell lines (HT-29). Results showed that when cells were exposed to ultra-small iron nanoparticles, their subcellular fate was mainly mitochondria, affecting its respiratory and glycolytic parameters, inducing the migration of the cellular state towards quiescence, and promoting and triggering the autophagic process. These effects support the potential use of nanoparticles as therapeutic agents using mitochondria as a target for cancer and other treatments for mitochondria-dependent pathologies.

Item Type:	Article
Commentary on:	Eprints 0 not found.
Uncontrolled Keywords:	Copy number, Metals, Mitochondria, MtDNA deletions, Nanotechnology, Respiration.
Subjects:	Subjects > Biomedicine
Divisions:	Europe University of Atlantic > Research > Scientific Production
SWORD Depositor:	Users 0 not found.
Depositing User:	Sr Bibliotecario
Date Deposited:	20 May 2021 11:09
Last Modified:	10 Jul 2023 07:26
URI:	http://repositorio.funiber.org/id/eprint/109

Available Versions of this Item

• Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration. (deposited 20 May 2021 11:09) [Currently Displayed]

Commentary/Response Threads

• Rivas-García, Lorenzo and Quiles, José L. and Varela-López, Alfonso and Giampieri, Francesca and Battino, Maurizio and Bettmer, Jörg and Montes-Bayón, María and Llopis, Juan and Sánchez-González, Cristina Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration. (deposited 20 May 2021 11:09) [Currently Displayed]

Actions (login required)

View Item