Cañadas-Lozano, Diego and Marín-Aguilar, Fabiola and Castejón-Vega, Beatriz and Ryffel, Bernhard and Navarro-Pando, José M. and Ruiz-Cabello, Jesús and Alcocer-Gómez, Elísabet and Bullón, Pedro and Cordero, Mario D. UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.navarro@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, mario.cordero@uneatlantico.es (2020) Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. GeroScience, 42 (2). pp. 715-725. ISSN 2509-2715
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Abstract
Aging is the major risk factor for many metabolic chronic diseases. Several metabolic pathways suffer a progressive impairment during aging including body composition and insulin resistance which are associated to autophagy dysfunction and increased inflammation. Many of these alterations are aggravated by non-healthy lifestyle such as obesity and hypercaloric diet which have been shown to accelerate aging. Here, we show that the deleterious effect of hypercaloric diets is reverted by the NLRP3 inflammasome inhibition. NLRP3 deficiency extends mean lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by metabolic health benefits including reduced liver steatosis and cardiac damage, improved glucose and lipid metabolism, and improved protein expression profiles of SIRT-1, mTOR, autophagic flux, and apoptosis. These findings suggest that the suppression of NLRP3 prevented many age-associated changes in metabolism impaired by the effect of hypercaloric diets.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | NLRP3 inflammasome; High-fat diet; Aging; Autophagy; Longevity; Obesity. |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 11:06 |
| Last Modified: | 15 Jun 2023 15:18 |
| URI: | http://repositorio.funiber.org/id/eprint/115 |
Available Versions of this Item
- Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. (deposited 20 May 2021 11:06) [Currently Displayed]
Commentary/Response Threads
- Cañadas-Lozano, Diego and Marín-Aguilar, Fabiola and Castejón-Vega, Beatriz and Ryffel, Bernhard and Navarro-Pando, José M. and Ruiz-Cabello, Jesús and Alcocer-Gómez, Elísabet and Bullón, Pedro and Cordero, Mario D. Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice. (deposited 20 May 2021 11:06) [Currently Displayed]
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