Giampieri, Francesca and Alvarez-Suarez, Jose M. and Gasparrini, Massimiliano and Forbes- Hernandez, Tamara Y. and Afrin, Sadia and Bompadre, Stefano and Rubini, Corrado and Zizzi, Antonio and Astolfi, Paola and Santos-Buelga, Celestino and González-Paramás, Ana M. and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2016) Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress. Food and Chemical Toxicology, 94. pp. 128-137. ISSN 0278-6915
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Abstract
Doxorubicin (Dox), one of the most used chemotherapeutic agents, is known to generate oxidative stress and block DNA synthesis, which result in severe dose-limiting toxicity. A strategy to protect against Dox toxic effects could be to use dietary antioxidants of which fruits and vegetable are a rich source. In this context, strawberry consumption is associated with the maintenance of good health and the prevention of several diseases, thanks to the antioxidant capacities of its bioactive compounds. The aim of the present study was to evaluate the protective effects of strawberry consumption against oxidative stress induced by Dox in rats. Animals were fed with strawberry enriched diet (15% of the total calories) for two months and Dox (10 mg/kg; i.p.) was injected at the end of the experimental period. Strawberry consumption significantly inhibited ROS production and oxidative damage biomarkers accumulation in plasma and liver tissue and alleviated histopathological changes in rat livers treated with Dox. The reduction of antioxidant enzyme activities was significantly mitigated after strawberry consumption. In addition, strawberry enriched diet ameliorated liver mitochondrial antioxidant levels and functionality. In conclusion, strawberry intake protects against Dox-induced toxicity, at plasma, liver and mitochondrial levels thanks to its high contents of bioactive compounds.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Strawberry, Bioactive compounds, Oxidative stress, Doxorubicin, Mitochondrial functionality. |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:53 |
| Last Modified: | 03 Mar 2022 12:13 |
| URI: | http://repositorio.funiber.org/id/eprint/147 |
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- Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress. (deposited 20 May 2021 10:53) [Currently Displayed]
Commentary/Response Threads
- Giampieri, Francesca and Alvarez-Suarez, Jose M. and Gasparrini, Massimiliano and Forbes- Hernandez, Tamara Y. and Afrin, Sadia and Bompadre, Stefano and Rubini, Corrado and Zizzi, Antonio and Astolfi, Paola and Santos-Buelga, Celestino and González-Paramás, Ana M. and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio Strawberry consumption alleviates doxorubicin-induced toxicity by suppressing oxidative stress. (deposited 20 May 2021 10:53) [Currently Displayed]
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