Rezabakhsh, Aysa and Safaei, Nasser and Nabavi, Seyed Mohammad and Roosta, Yousef and Giampieri, Francesca and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2025) Anti-atherogenic immune checkpoint TIM-3 as a promising pharmacologic target toward ischemic heart diseases: a prospective review. Molecular Biology Reports, 52 (1). ISSN 0301-4851
Full text not available from this repository.Abstract
Recently, immunogene therapy has been of great interest in cardiovascular diseases. In this regard, various immune checkpoint inhibitors (ICIs) are identified to have a crucial role in regulating inflammatory responses. The T-cell immunoglobulin and mucin-domain containing molecule-3 (TIM-3, CD366), a relatively newly discovered group of molecules with a conserved structure, has emerged as a critical immune checkpoint with significant regulatory roles in cardiovascular inflammation and atherosclerosis. This prospective review explores the importance of TIM-3 in modulating immune responses relevant to ischemic heart diseases (IHD), highlighting its interactions with inflammatory pathways such as Toll-like receptor-4 (TLR-4). TIM-3, predominantly expressed on T cells, dendritic cells, and monocytes, acts as an inhibitory receptor that quenches pro-inflammatory signaling, particularly upon binding to ligands like galectin-9. Noteworthy, recent evidence suggests that TIM-3 deficiency or dysregulation can exacerbate inflammatory cascades, contributing to the progression of IHD and related complications. Here, the therapeutic potential of targeting TIM-3 for the management of IHD, especially in the settings of systemic inflammation and post-operative complications, has been discussed. By elucidating the molecular mechanisms and translational prospects of TIM-3 modulation, this work proposes new avenues for immunotherapeutic intervention in cardiovascular disease and post-operative SIRS, warranting further research in clinical trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Immune checkpoint inhibitors; Ischemic heart diseases Inflammatory heart disease; Systemic inflammatory reaction syndrome (SIRS); T-cell immunoglobulin and mucin domain 3 |
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 05 Sep 2025 10:07 |
| Last Modified: | 05 Sep 2025 10:07 |
| URI: | http://repositorio.funiber.org/id/eprint/17835 |
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