Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Esteban-Muñoz, Adelaida and Sánchez-González, Cristina and Rivas-García, Lorenzo and Llopis, Juan and Cianciosi, Danila and Giampieri, Francesca and Sumalla Cano, Sandra and Battino, Maurizio and Quiles, José L. UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, sandra.sumalla@uneatlantico.es, maurizio.battino@uneatlantico.es, jose.quiles@uneatlantico.es (2022) Strawberry (Fragaria × ananassa cv. Romina) methanolic extract attenuates Alzheimer’s beta amyloid production and oxidative stress by SKN-1/NRF and DAF-16/FOXO mediated mechanisms in C. elegans. Food Chemistry, 372. p. 131272. ISSN 03088146
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Abstract
Bioactive compounds from strawberries have been associated with multiple healthy benefits. The present study aimed to assess chemical characterization of a methanolic extract of the Romina strawberry variety in terms of antioxidant capacity, polyphenols profile and chemical elements content. Additionally, potential toxicity, the effect on amyloid-β production and oxidative stress of the extract was in vivo evaluated in the experimental model Caenorhabditis elegans. Results revealed an important content in phenolic compounds (mainly ellagic acid and pelargonidin-3-glucoside) and minerals (K, Mg, P and Ca). The treatment with 100, 500 or 1000 μg/mL of strawberry extract did not show toxicity. On the contrary, the extract was able to delay amyloid β-protein induced paralysis, reduced amyloid-β aggregation and prevented oxidative stress. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2 signaling pathways were, at least partially, involved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Berries; Antioxidant; Anthocyanins; Minerals; RNAi; ROS |
| Subjects: | Subjects > Biomedicine Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 07 Mar 2022 13:02 |
| Last Modified: | 17 Jul 2023 09:27 |
| URI: | http://repositorio.funiber.org/id/eprint/517 |
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