Giampieri, Francesca and Alvarez-Suarez, Josè M. and Cordero, Mario D. and Gasparrini, Massimiliano and Forbes-Hernandez, Tamara Y. and Afrin, Sadia and Santos-Buelga, Celestino and González-Paramás, Ana M. and Astolfi, Paola and Rubini, Corrado and Zizzi, Antonio and Tulipani, Sara and Quiles, Josè L. and Mezzetti, Bruno and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, tamara.forbes@unini.edu.mx, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, maurizio.battino@uneatlantico.es (2017) Strawberry consumption improves aging-associated impairments, mitochondrial biogenesis and functionality through the AMP-activated protein kinase signaling cascade. Food Chemistry, 234. pp. 464-471. ISSN 03088146
Full text not available from this repository.Abstract
Dietary polyphenols have been recently proposed as activators of the AMP-activated protein kinase (AMPK) signaling pathway and this fact might explain the relationship between the consumption of polyphenol-rich foods and the slowdown of the progression of aging. In the present work, the effects of strawberry consumption were evaluated on biomarkers of oxidative damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old rats. Strawberry supplementation increased antioxidant enzyme activities, mitochondrial biomass and functionality, and decreased intracellular ROS levels and biomarkers of protein, lipid and DNA damage (P<0.05). Furthermore, a significant (P<0.05) increase in the expression of the AMPK cascade genes, involved in mitochondrial biogenesis and antioxidant defences, was also detected after strawberry intake. These in vivo results were then verified in vitro on HepG2 cells, confirming the involvement of AMPK in the beneficial effects exerted by strawberry against aging progression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AMPK activation; Aging; Mitochondrial functionality; Oxidative stress; Strawberry polyphenols. |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 15 Mar 2022 10:41 |
| Last Modified: | 15 Mar 2022 10:41 |
| URI: | http://repositorio.funiber.org/id/eprint/563 |
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