Cianciosi, Danila and Forbes-Hernández, Tamara Y. and Regolo, Lucia and Alvarez-Suarez, José M. and Quinzi, Denise and Sargenti, Azzurra and Bai, Weibin and Tian, Lingmin and Giampieri, Francesca and Battino, Maurizio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, maurizio.battino@uneatlantico.es (2022) Manuka honey in combination with 5-Fluorouracil decreases physical parameters of colonspheres enriched with cancer stem-like cells and reduces their resistance to apoptosis. Food Chemistry, 374. p. 131753. ISSN 03088146
Full text not available from this repository.Abstract
The aim of the present work was to evaluate the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate. Manuka honey, alone and more in combination with 5-Fu, reduced the weight, the diameter and mass density of the spheroids and induced apoptosis through the downregulation of many apoptosis inhibitors, including IAPs (Livin, Survivin, XIAP), IGFs (IGF-I, IGF-II and IGF-IR) and HSPs (HSP-27, HSP-60 and HSP-70). These results led to a reduction in the survival ability of cancer stem-like cells, as well as to a chemosensitizing effect of honey towards 5-Fu, considering that apoptosis resistance is one of the main causes of cancer stem-like cells chemoresistance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Apoptosis; Cancer; Chemosensibility; Honey; Spheroids; Stemness. |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 15 Mar 2022 10:54 |
| Last Modified: | 13 Jul 2023 07:02 |
| URI: | http://repositorio.funiber.org/id/eprint/564 |
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