García-García, Amalia and Rojas, Sara and Rivas-García, Lorenzo and Navarro-Hortal, María D. and Romero-Márquez, Jose M. and Fernández-Bolaños, José G. and Choquesillo-Lazarte, Duane and Salinas-Castillo, Alfonso and López, Óscar and Quiles, José L. and Rodríguez-Diéguez, Antonio UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es, UNSPECIFIED (2022) A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans. Chemical Communications, 58 (10). pp. 1514-1517. ISSN 1359-7345
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Abstract
A new palladium coordination compound based on gliclazide with the chemical formula [Pd(glz)2] (where glz = gliclazide) has been synthesized and characterised. The structural characterization reveals that this material consists of mononuclear units formed by a Pd2+ ion coordinated to two molecules of the glz ligand, in which palladium ions exhibit a distorted plane-square coordination sphere. This novel material behaves like a good and selective inhibitor of butyrylcholinesterase, one of the most relevant therapeutic targets against Alzheimer's disease. Analysis of the enzyme kinetics showed a mixed mode of inhibition, the title compound being capable of interacting with both the free enzyme and the enzyme-substrate complex. Finally, the palladium compound shows promising protective activity against Aβ-induced toxicity in the Caenorhabditis elegans model, which has never been reported.
| Item Type: | Article |
|---|---|
| Subjects: | Subjects > Biomedicine |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 17 Mar 2022 14:34 |
| Last Modified: | 11 Jul 2023 07:52 |
| URI: | http://repositorio.funiber.org/id/eprint/584 |
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