Romero-Márquez, Jose M. and Navarro-Hortal, María D. and Jiménez-Trigo, Victoria and Vera-Ramírez, Laura and Forbes-Hernández, Tamara J. and Esteban-Muñoz, Adelaida and Giampieri, Francesca and Bullón, Pedro and Battino, Maurizio and Sánchez-González, Cristina and Quiles, José L. UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, francesca.giampieri@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, jose.quiles@uneatlantico.es (2022) An oleuropein rich-olive (Olea europaea L.) leaf extract reduces β-amyloid and tau proteotoxicity through regulation of oxidative- and heat shock-stress responses in Caenorhabditis elegans. Food and Chemical Toxicology, 162. p. 112914. ISSN 02786915
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Abstract
Olive tree-derived products have been associated with numerous benefits for health. The aim of the present study was to characterize an olive leaf extract enriched in oleuropein (OLE) concerning phenolic content and profile as well as antioxidant capacity. Short-term and long-term toxicity, including oxidative stress, was in vivo evaluated in the experimental model Caenorhabditis elegans. Moreover, the potential therapeutic effect of the extract against Aβ induced- and tau protein induced-toxicity was also evaluated in C. elegans. OLE treatment did not exert toxicity. On the contrary, the extract was able to ameliorate oxidative stress and proteotoxicity related to Aβ and tau aggregation. The potential molecular mechanisms present behind the observed results explored by RNAi technology revealed that DAF-16/FOXO and SKN-1/NRF2, elements of the insulin insulin-like signalling pathway, as well as HSP-16.2 overexpression were involved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Alzheimer disease; DAF-16/FOXO; HSP-16.2; IIS pathway; RNAi; SKN-1/NRF2 |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 30 Mar 2022 10:12 |
| Last Modified: | 11 Jul 2023 09:35 |
| URI: | http://repositorio.funiber.org/id/eprint/597 |
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