Ansary, Johura and Giampieri, Francesca and Forbes-Hernandez, Tamara Y. and Regolo, Lucia and Quinzi, Denise and Gracia Villar, Santos and Garcia Villena, Eduardo and Tutusaus, Kilian and Alvarez-Suarez, José M. and Battino, Maurizio and Cianciosi, Danila UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED, santos.gracia@uneatlantico.es, eduardo.garcia@uneatlantico.es, kilian.tutusaus@uneatlantico.es, UNSPECIFIED, UNSPECIFIED, UNSPECIFIED (2021) Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. Molecules, 26 (8). p. 2108. ISSN 1420-3049
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Abstract
In recent times, scientific attention has been paid to different foods and their bioactive components for the ability to inhibit the onset and progress of different types of cancer. Nigella sativa extract, powder and seed oil and its main components, thymoquinone and α-hederin, have showed potent anticancer and chemosensitizing effects against various types of cancer, such as liver, colon, breast, renal, cervical, lung, ovarian, pancreatic, prostate and skin tumors, through the modulation of various molecular signaling pathways. Herein, the purpose of this review was to highlight the anticancer activity of Nigella sativa and it constitutes, focusing on different in vitro, in vivo and clinical studies and projects, in order to underline their antiproliferative, proapoptotic, cytotoxic and antimetastatic effects. Particular attention has been also given to the synergistic effect of Nigella sativa and it constitutes with chemotherapeutic drugs, and to the synthesized analogs of thymoquinone that seem to enhance the chemo-sensitizing potential. This review could be a useful step towards new research on N. sativa and cancer, to include this plant in the dietary treatments in support to conventional therapies, for the best achievement of therapeutic goals.
| Item Type: | Article |
|---|---|
| Commentary on: | Eprints 0 not found. |
| Uncontrolled Keywords: | Nigella sativa, Nutritional composition, Anticancer properties, Molecular pathways, Combined therapy. |
| Subjects: | Subjects > Nutrition |
| Divisions: | Europe University of Atlantic > Research > Scientific Production Ibero-american International University > Research > Scientific Production |
| SWORD Depositor: | Users 0 not found. |
| Depositing User: | Sr Bibliotecario |
| Date Deposited: | 20 May 2021 10:43 |
| Last Modified: | 07 Jul 2023 08:14 |
| URI: | http://repositorio.funiber.org/id/eprint/77 |
Available Versions of this Item
- Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. (deposited 20 May 2021 10:43) [Currently Displayed]
Commentary/Response Threads
- Ansary, Johura and Giampieri, Francesca and Forbes-Hernandez, Tamara Y. and Regolo, Lucia and Quinzi, Denise and Gracia Villar, Santos and Garcia Villena, Eduardo and Tutusaus, Kilian and Alvarez-Suarez, José M. and Battino, Maurizio and Cianciosi, Danila Nutritional Value and Preventive Role of Nigella sativa L. and Its Main Component Thymoquinone in Cancer: An Evidenced-Based Review of Preclinical and Clinical Studies. (deposited 20 May 2021 10:43) [Currently Displayed]
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